ASCORBATE IN HEALTHY-SUBJECTS, AMYOTROPHIC-LATERAL-SCLEROSIS AND ALZHEIMERS-DISEASE

Authors
PARASKEVAS GP KAPAKI E LIBITAKI G ZOURNAS C SEGDITSA I PAPAGEORGIOU C
Citation
Gp. Paraskevas et al., ASCORBATE IN HEALTHY-SUBJECTS, AMYOTROPHIC-LATERAL-SCLEROSIS AND ALZHEIMERS-DISEASE, Acta neurologica Scandinavica, 96(2), 1997, pp. 88-90
Citations number
27
Categorie Soggetti
Clinical Neurology
Journal title
Acta neurologica Scandinavica → ACNP
ISSN journal
00016314
Volume
96
Issue
2
Year of publication
1997
Pages
88 - 90
Database
ISI
SICI code
0001-6314(1997)96:2<88:AIHAAA>2.0.ZU;2-V
Abstract
The aim of the present study was to report the levels of ascorbic acid in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) a nd the effectiveness of ascorbic acid homeostasis in the central nervo us system. Plasma and CSF ascorbic acid levels were measured by high p erformance liquid chromatography in 19 ALS patients, 17 AD patients an d 15 controls. No statistically significant difference was found betwe en patients and controls. However, wide fluctuations of plasma concent rations were found to result in relatively stable CSF levels, by appro priate adjustments of CSF/plasma ratio. It appears that in normal subj ects and in the diseases under study, this ratio reflects the activity of the choroid plexus ascorbate transporter.