Chemistry and biotransformations in the Scrophulariaceae family

One of our research lines has been the chemical studies among Calceolaria s pecies (Scrophulariaceae), from which have been isolated 77 new diterpenes of various skeleton types (labdanes, pimaranes, stemaranes, and stemodanes) , all coming from a common bicyclic intermediate, having H-9 and C-20 as a cis relationship and C-ll becomes trans with respect to C-20. Another line of research is bringing out chemical changes on diterpenes obtained from th is family, using biological systems as the fungus Giberella fujikuroi and M ucor plumbeus.