The genetics of chronic obstructive pulmonary disease

Authors
Lomas, DA Silverman, EK
Citation
Da. Lomas et Ek. Silverman, The genetics of chronic obstructive pulmonary disease, RESPIR RES, 2(1), 2001, pp. 20-26
Citations number
70
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
RESPIRATORY RESEARCH
ISSN journal
1465993X → ACNP
Volume
2
Issue
1
Year of publication
2001
Pages
20 - 26
Database
ISI
SICI code
1465-993X(2001)2:1<20:TGOCOP>2.0.ZU;2-Q
Abstract
Chronic obstructive pulmonary disease (COPD) is a significant cause of glob al morbidity and mortality. Previous studies have shown that COPD aggregate s in families, suggesting a genetic predisposition to airflow obstruction. Many candidate genes have been assessed, but the data are often conflicting . We review the genetic factors that predispose smokers to COPD and highlig ht the future role of genomic scans in identifying novel susceptibility gen es.