Angiomyofibroblastoma of the vulva: Report of a case

A 45-year-old woman was first seen by us 2 years after becoming aware of a slightly painful subcutaneous mass in her left vulva. The mass was 7.5 x 3. 0 cm in size, well circumscribed, mobile, and rubbery. It was at first clin ically considered to be a benign tumor. Microscopically, the resected mass was composed of spindle or polygonal tumor cells which were cellularly or h ypocellularly arranged with perivascular accentuation in a mucoid or fibroc ollagenous background. Immunohistochemically, myxoid tumor cells were posit ive for vimentin but not for ct-smooth muscle actin, CD34, CD31, desmin, or S-100 protein. The tumor was diagnosed as an angiomyofibroblastoma (AMBF), based on the typical findings of histology and immunohistochemistry. There are many histological types of vulvar tumors, and establishing a preoperat ive diagnosis is difficult in many patients. Rapid intraoperative pathologi cal diagnosis should be performed if possible, considering the possibility of diseases such as AMFB and aggressive angiomyxoma (AAM). When AAM is susp ected, the peripheral tissues should also be resected to prevent recurrence .