Anticocaine catalytic antibodies have no affinity for RTI compounds: Implications for treatment

Potential medications for cocaine abusers include: anticocaine catalytic an tibodies, which could serve as circulating peripheral blockers of cocaine t hat prevents its action in the brain; and 3-phenyltropane cocaine analogs, which could serve as potent, selective, and long-lasting substitutes that r educe drug-seeking. In order to evaluate the compatibility of these agents, we measured if a catalytic antibody would bind and interact with some coca ine analogs. Anticocaine catalytic antibody 15A10 had no significant affini ty for RTI-51, RTI-112, or RTI-177 as examined by ELISA. They exhibited hig h affinity for the immunogen TSA1 in the same experiment, as expected. Beca use the antibody and the RTI compounds do not interact, they are candidates for simultaneous use. (C) 2001 Wiley-Liss, Inc.