Activation of C-H bonds alpha to nitriles for combinatorial chemistry: Ruthenium-catalyzed aldol and Michael reactions of polymer-supported nitriles

Authors
Takaya, H Murahashi, SI
Citation
H. Takaya et Si. Murahashi, Activation of C-H bonds alpha to nitriles for combinatorial chemistry: Ruthenium-catalyzed aldol and Michael reactions of polymer-supported nitriles, SYNLETT, 2001, pp. 991-994
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Year of publication
2001
Pages
991 - 994
Database
ISI
SICI code
0936-5214(2001):<991:AOCBAT>2.0.ZU;2-8
Abstract
Catalytic activation of C-H bonds adjacent to nitriles supported by Wang re sin can be performed with ruthenium dihydride complex RuH2(PPh3)(4) (1). Al dol and Michael reactions of the solid-supported cyanoacetates proceed to g ive the corresponding adducts in good yields under mild and neutral conditi ons. Four-component reactions that include sequential aldol-Michael-Michael reaction by C-H activation take place diastereoselectively.