Electrophilic sulfoalkylation reagents, such as 1,3-propanesultone, are wid
ely used to enhance the hydrophilicity of polymers, proteins, etc. In this
report, a series of nucleophilic sulfoalkylation reagents [NH2O(CH2)(n)SO3H
, n = 2, 3, 4] were prepared from the corresponding chloroalkylsulfonyl chl
orides. (C) 2001 Elsevier Science Ltd. All rights reserved.