New crystal forms of Trypanosoma cruzi dUTPase

The dUTPase from Trypanosoma cruzi has been crystallized in two crystal for ms, both belonging to space group P6(3)22, with unit-cell parameters a = b = 134.67, c = 148.66 Angstrom (form I, two molecules per asymmetric unit) a nd a = b = 136.43, c = 68.71 Angstrom (form II, one molecule per asymmetric unit). Single-wavelength data have been collected using synchrotron radiat ion to 3.0 Angstrom for crystal form I and to 2.4 Angstrom for crystal form II and structure solution is under way. T. cruzi dUTPase is a potential ta rget for anti-protozoan drug design.