Prospective randomized trial of polyglactin 910 mesh to prevent recurrenceof cystoceles and rectoceles

OBJECTIVE: Our aim was to evaluate the efficacy of polyglactin 910 mesh in preventing recurrent cystoceles and rectoceles. STUDY DESIGN: in a prospective, randomized, controlled trial, patients unde rgoing vaginal reconstructive surgery with cystoceles to the hymenal ring a nd beyond were randomly selected to undergo anterior and posterior colporrh aphy with or without polyglactin 910 mesh reinforcement. Results were evalu ated preoperatively and at 2, 6, 12, and 52 weeks postoperatively. RESULTS: A total of 161 women were randomly selected for this study. One wo man was excluded at the time of surgery, and 17 women were lost to follow-u p. Eighty women received mesh, and 80 did not. Both groups were found to be equivalent with respect to age, parity, concomitant surgery, and menopausa l and hormone replacement status. Preoperatively 49 women had a central cys tocele to the hymenal ring and 111 women had cystoceles beyond the introitu s; 91 women had a rectocele to the mid-vaginal plane, 31 to the hymenal rin g, and 22 beyond the introitus. After 1 year, 30 (43%) of 70 subjects witho ut mesh and 18 (25%) of 73 subjects with mesh had recurrent cystoceles beyo nd the mid-vaginal plane (P = .02). Eight women without mesh and 2 women wi th mesh had recurrent cystoceles to the hymenal ring (P = .04). No recurren t cystoceles beyond the hymenal ring occurred in either group. Multivariate logistic regression analysis showed concurrent slings to be associated wit h significantly fewer recurrent cystoceles (odds ratio, 0.32; P = .005), wh ereas the presence of mesh remained significantly predictive of fewer cysto cele recurrences in this analysis. Thirteen recurrent rectoceles were noted 1 year postoperatively, with no differences between groups. CONCLUSION: Polyglactin 910 mesh was found to be useful in the prevention o f recurrent cystoceles.