Dermal absorption and distribution of C-14 carbaryl in Wistar rats

The level of C-14 carbaryl was determined in blood (leukocytes, erythrocyte s, ail blood cells, plasma) and organs (brain, heart, lungs, liver, spleen, skin at the: site of exposure) of male Wister rats after dermal administra tion. The application liquid was C-14 carbaryl solution in 96% ethyl alcoho l. This preparation. possessing an activity of 670 kBq/ml, containing 1.67 mg of carbaryl, was applied to the skin of the tail according to Massmann's method in own modification. The amount of the preparation per 1 cm(2) of t he tail skin was 0.19 mg of carbaryl (74.4 kBq). The rails of experimental rats were exposed to C-14 carbaryl bp soaking for 4 h daily: once, twice or three times. Beta radiation from C-14 was measured in homogenized organs ( brain, heart, lungs, liver, skin) and in blood by computer controlled Walla c scintillation counter Model 1409, using Multi Gale software. The dermal a bsorption of carbaryl at the site of exposure and in the surrounding area o f about 2 cm was observed already during 4 hour exposure. Carbaryl reached plasma within 4 h of a single dermal exposure and penetrated into leukocyte s, erythrocytes, heart, liver, lung, kidney and brain. The largest amount o f C-14 carbaryl, about 2% of absorbed dose, was detected in liver.