Churg-Strauss syndrome

Objectives: This article discusses the clinical manifestations and treatmen t protocols of Churg-Strauss syndrome (CSS). A review of the definition, pa thophysiology, and prognosis of CSS is included, as well as more recent evi dence of the presumed association between antileukotriene antagonists and C SS. Data sources: Relevant articles in the medical literature derived from sear ching the MEDLINE database (1966 to present) with key terms Churg-Strauss s yndrome, allergic granulomatosis, and allergic granulomatous angiitis. Sour ces included review articles, meta-analyses, randomized control trials, cas e reports, case series, and seminal articles, the majority of which had bee n published within the past decade. Study selection: Studies that described the clinical manifestations, pathophysiology, etiology, treatment, or prog nosis of CSS. Results: CSS is a systemic vasculitic disorder with multiorgan involvement and diverse presentations. Conclusions: Recognition of the multiorgan manifestations of CSS is crucial to clinical management. Whether a causal relationship exists between antil eukotriene antagonists and onset of CSS remains unclear.