J. Gerber et al., Activity of LY333328 in experimental meningitis caused by a Streptococcus pneumoniae strain susceptible to penicillin, ANTIM AG CH, 45(7), 2001, pp. 2169-2172
In a rabbit model of Streptococcus pneumoniae meningitis single doses of 10
and 2.5 mg of the glycopeptide LY333328 per kg of body weight reduced bact
erial titers in cerebrospinal fluid (CSF) almost as rapidly as ceftriaxone
at 10 mg/kg/h (changes in log CPU, -0.29 +/- 0.21 and -0.26 +/- 0.22 versus
-0.34 +/- 0.15/ml/h). A dose of 1 mg/kg was bacteriostatic (change in log
CPU, 0.01 +/- 0.11/ml/h). In two animals receiving LY333328 at a dose of 40
mg/kg the bacterial titers were reduced by 0.54 and 0.51 log CFU/ml/h. The
penetration of CSF by LY333328 was 1 to 5%. The concentrations of lipoteic
hoic and teichoic acids in CSF and neuronal damage were similar in ceftriax
one- and LY333328-treated animals.