Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy

Authors
Villani, P Viale, P Signorini, L Cadeo, B Marchetti, F Villani, A Fiocchi, C Regazzi, MB Carosi, G
Citation
P. Villani et al., Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy, ANTIM AG CH, 45(7), 2001, pp. 2160-2162
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
7
Year of publication
2001
Pages
2160 - 2162
Database
ISI
SICI code
0066-4804(200107)45:7<2160:PEOOLI>2.0.ZU;2-F
Abstract
The purpose of this study was to evaluate the pharmacokinetics (PK) profile of oral levofloxacin in human immunodeficiency virus-positive patients in steady-state treatment with nelfinavir (NFV) or with efavirenz (EFV) and to determine the effects of levofloxacin on the PR parameters of these two an tiretroviral agents. For levofloxacin, plasma samples were obtained at stea dy state during a 24-h dosing interval. Plasma NFV and EFV concentrations w ere evaluated before and after 4 days of levofloxacin treatment. Levofloxac in PI( do not seem affected by NFV and EFV. There was no significant differ ence between NFV and EFV plasma levels obtained with and without levofloxac in.