Synthesis of new salicylamide derivatives with evaluation of their antiinflammatory, analgesic and antipyretic activities

A new series of pyridazine, pyrazoles, pyrazolidine-3,5-dione, Semicarbazid e, thiosemicarbazides, hydantoin, thiohydantoins, 1,2,4-triazoles, S-triazo lo[3,4-b]-1,3,4-thiadiazoles incorporated indirectly into salicylamide moie ty at position 2 were synthesized. Also the synthesis of novel series of 3- salicylamido-2-hydroxypropyl-amine derivatives were prepared. Several of th ese compounds were screened for antiinflammatory, analgesic, antipyretic an d ulcerogenic activities.