Inhibition of calmodulin-dependent Calcium-ATPase and phosphodiesterase byvarious cyclopeptides and peptide alkaloids from the Zizyphus species

Authors
Hwang, KH Han, YN Han, BH
Citation
Kh. Hwang et al., Inhibition of calmodulin-dependent Calcium-ATPase and phosphodiesterase byvarious cyclopeptides and peptide alkaloids from the Zizyphus species, ARCH PH RES, 24(3), 2001, pp. 202-206
Citations number
28
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
24
Issue
3
Year of publication
2001
Pages
202 - 206
Database
ISI
SICI code
0253-6269(200106)24:3<202:IOCCAP>2.0.ZU;2-V
Abstract
The effects of various sedative cyclopeptides and peptide alkaloids from th e Zizyphus species on calmodulin-dependent Ca2+-ATPase and phosphodiesteras e were investigated. Calmodulin-induced activation of Ca2+-ATPase was stron gly inhibited by sanjoinine-A dialdehyde (IC50, 2.3 muM), -Ah1 (IC50, 4.0 m uM), -A (IC50, 4.6 muM), and -G2 (IC50, 7.2 muM), while calmodulin-induced activation of phosphodiesterase was strongly inhibited by both deachuine-S1 0 (IC50, 4.9 muM) and sanjoinine-D (IC50, 9.0 muM). The inhibitory activity of the various cyclopeptides and peptide alkaloids on Ca2+-ATPase was foun d to correlate well with their sedative activity.