B-CELL-DEFICIENT MU-MT MICE AS AN EXPERIMENTAL-MODEL FOR MYCOPLASMA-INFECTIONS IN X-LINKED AGAMMAGLOBULINEMIA

Authors
BERGLOF A SANDSTEDT K FEINSTEIN R BOLSKE G SMITH CIE
Citation
A. Berglof et al., B-CELL-DEFICIENT MU-MT MICE AS AN EXPERIMENTAL-MODEL FOR MYCOPLASMA-INFECTIONS IN X-LINKED AGAMMAGLOBULINEMIA, European Journal of Immunology, 27(8), 1997, pp. 2118-2121
Citations number
25
Categorie Soggetti
Immunology
Journal title
European Journal of Immunology → ACNP
ISSN journal
00142980
Volume
27
Issue
8
Year of publication
1997
Pages
2118 - 2121
Database
ISI
SICI code
0014-2980(1997)27:8<2118:BMMAAE>2.0.ZU;2-N
Abstract
B cell-deficient mu MT mice were investigated as an experimental model for human X-linked agammaglobulinemia (XLA). Mice were intranasally i nfected with Mycoplasma pulmonis and in 16 out of 17 mu MT mice, disse mination of the bacteria from the airways was observed. More than 50% of these mice developed arthritis and/or changes in periarticular tiss ues. Myycoplasmal infection in mu MT mice thus resembles the disease s een in XLA patients implying the usefulness of the model.