Enantioselective synthesis and complement inhibitory assay of A/B-ring partial analogues of oleanolic acid

Authors
Assefa, H Nimrod, A Walker, L Sindelar, R
Citation
H. Assefa et al., Enantioselective synthesis and complement inhibitory assay of A/B-ring partial analogues of oleanolic acid, BIOORG MED, 11(13), 2001, pp. 1619-1623
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
13
Year of publication
2001
Pages
1619 - 1623
Database
ISI
SICI code
0960-894X(20010709)11:13<1619:ESACIA>2.0.ZU;2-5
Abstract
A series of oleanolic acid A/B-ring partial analogues was synthesized and t ested for their complement inhibitory activity as well as cytotoxic propert ies. All target compounds and one intermediate exhibited moderate complemen t inhibitory potency. These compounds also showed cytotoxicity on malignant melanoma cell line, SK-MEL. (C) 2001 Elsevier Science Ltd. All rights rese rved.