Dibasic inhibitors of human mast cell tryptase. Part 3: Identification of a series of potent and selective inhibitors containing the benzamidine functionality

Authors
Dener, JM Rice, KD Newcomb, WS Wang, VR Young, WB Gangloff, AR Kuo, EYL Cregar, L Putnam, D Wong, M
Citation
Jm. Dener et al., Dibasic inhibitors of human mast cell tryptase. Part 3: Identification of a series of potent and selective inhibitors containing the benzamidine functionality, BIOORG MED, 11(13), 2001, pp. 1629-1633
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
13
Year of publication
2001
Pages
1629 - 1633
Database
ISI
SICI code
0960-894X(20010709)11:13<1629:DIOHMC>2.0.ZU;2-V
Abstract
A survey of charged groups and linkers for a series of symmetrical and unsy mmetrical dibasic inhibitors is described. leading to several classes of po tent and selective inhibitors. In particular. the benzamidine functionality was identified as the most potent charged group investigated. (C) 2001 Els evier Science Ltd. All rights reserved.