Quinoline-4-acetamides as sPLA(2) inhibitors

Authors
Liu, Y Feng, YB Wang, RX Gao, Y Lai, LH
Citation
Y. Liu et al., Quinoline-4-acetamides as sPLA(2) inhibitors, BIOORG MED, 11(13), 2001, pp. 1639-1641
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
13
Year of publication
2001
Pages
1639 - 1641
Database
ISI
SICI code
0960-894X(20010709)11:13<1639:QASI>2.0.ZU;2-G
Abstract
Quinoline-4-acetamides were designed as potential phospholipase Al inhibito rs by structural based method and synthesized. The chemical structures of t he obtained compounds were confirmed by elemental analyses, H-1 NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certa in inhibition to sPLA(2). (C) 2001 Elsevier Science Ltd. All rights reserve d.