Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase

Authors
Martin, JA Lambert, RW Merrett, JH Parkes, KEB Thomas, GJ Baker, SJ Bushnell, DJ Cansfield, JE Dunsdon, SJ Freeman, AC Hopkins, RA Johns, IR Keech, E Simmonite, H Walmsley, A Kai-In, PW Holland, M
Citation
Ja. Martin et al., Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase, BIOORG MED, 11(13), 2001, pp. 1655-1658
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
13
Year of publication
2001
Pages
1655 - 1658
Database
ISI
SICI code
0960-894X(20010709)11:13<1655:NAAHPA>2.0.ZU;2-K
Abstract
A series of carboxamide derivatives of 5 ' -amino-2 ' ,5 ' -dideoxy-5-ethyl uridine has been prepared as inhibitors of HSV-TK (herpes simplex virus thy midine kinase). The most potent compounds were derived from xanthene, thiox anthene and dihydroanthracene carboxylic acids. The lead compounds show sub nanomolar IC50 values against HSV TKs. (C) 2001 Elsevier Science Ltd. All r ights reserved.