Novel sulfonate derivatives: Potent antimitotic agents

Authors
Gwaltney, SL Imade, HM Li, Q Gehrke, L Credo, RB Warner, RB Lee, JY Kovar, P Frost, D Ng, SC Sham, HL
Citation
Sl. Gwaltney et al., Novel sulfonate derivatives: Potent antimitotic agents, BIOORG MED, 11(13), 2001, pp. 1671-1673
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
13
Year of publication
2001
Pages
1671 - 1673
Database
ISI
SICI code
0960-894X(20010709)11:13<1671:NSDPAA>2.0.ZU;2-Q
Abstract
The synthesis and biological evaluation of novel sulfonate analogues of E-7 010 are reported, Several of the compounds are potent inhibitors of cell pr oliferation and tubulin polymerization. Importantly, these compounds are al so active against P-glycoprotein positive (+)cancer cells, which are resist ant to many other antitumor agents. (C) 2001 Elsevier Science Ltd. All righ ts reserved.