Total synthesis of human chymase inhibitor methyllinderone and structure-activity relationships of its derivatives

Authors
Aoyama, Y Konoike, T Kanda, A Naya, N Nakajima, M
Citation
Y. Aoyama et al., Total synthesis of human chymase inhibitor methyllinderone and structure-activity relationships of its derivatives, BIOORG MED, 11(13), 2001, pp. 1695-1697
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
13
Year of publication
2001
Pages
1695 - 1697
Database
ISI
SICI code
0960-894X(20010709)11:13<1695:TSOHCI>2.0.ZU;2-Y
Abstract
Total synthesis of human chymase inhibitor methyllinderone has been achieve d in only four steps with an overall yield of 21% from dimethyl squarate. W e developed an efficient synthetic method for obtaining methyllinderone der ivatives and found the active compound. In addition, we propose the inhibit ion mechanism of the active compound against human chymase using calculatio ns. (C) 2001 Elsevier Science Ltd. All rights reserved.