Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: Mass spectral evidence for the flavin adduct

Authors
Mitchell, DJ Nikolic, D van Breemen, RB Silverman, RB
Citation
Dj. Mitchell et al., Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: Mass spectral evidence for the flavin adduct, BIOORG MED, 11(13), 2001, pp. 1757-1760
Citations number
33
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
13
Year of publication
2001
Pages
1757 - 1760
Database
ISI
SICI code
0960-894X(20010709)11:13<1757:IOMOBB>2.0.ZU;2-W
Abstract
Incubation of 1-phenylcyclopropylamine with bovine liver MAO (MAO B), follo wed by complete enzymatic digestion to single amino acid residues and subse quent analysis by on-line liquid chromatography-electrospray ionization mas s spectrometry, was used to investigate the resulting flavin adduct structu re. (C) 2001 Elsevier Science Ltd. All rights reserved.