Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase

Based upon synthetic and biochemical results, a novel and potent tacrine an alogue and heterobivalent analogues of tacrine, were designed. The role pla yed by the amino groups of homo- and heterobivalent ligands in the interact ion with the peripheral and catalytic sites of AChE and BuChE were investig ated. The syntheses of these materials together with the results of AChE/Bu ChE inhibition assays are detailed. (C) 2001 Elsevier Science Ltd. All righ ts reserved.