Prognostic factors and response to fludarabine therapy in patients with Waldenstrom macroglobulinemia: results of United States intergroup trial (Southwest Oncology Group S9003)

Current information on Waldenstrom macroglobulinemia (WM) is based on retro spective or single-institution studies of patients requiring therapy. Betwe en 1992 and 1998, 231 patients with WM were enrolled in a prospective obser vational multicenter clinical trial, Of these, 182 patients with symptomati c or progressive disease were treated with 4 to 8 cycles of therapy with a purine nucleoside analogue, fludarabine (FAMP; 30 mg/m(2) of body-surface a rea daily for 5 days every 28 days). A serum beta2-microglobulin (beta 2M) level below 3 mg/L and a hemoglobin level of at least 120 g/L (12 g/dL) at presentation predicted a lower likelihood of requiring therapy. The overall rate Of response to FAMP therapy was 36% (95% confidence interval, 29%-44% ), with 2% complete remissions. Patients who were 70 years old or older had a substantially lower likelihood of response (odds ratio, 0.34; P = .004) than younger patients. On multivariate analysis, a serum beta 2M level of 3 mg/L or higher, hemoglobin level below 120 g/L, and serum IgM level below 40 g/L [4 g/dL] were significant adverse prognostic factors for survival. W e developed a simple staging system for WM by using these variables and ide ntified 4 distinct subsets of patients with estimated 5-year overall surviv al rates of 87%, 64%, 53%, and 22%, and 5-year progression-free survival ra tes of 83%, 55%, 33%, and 12%. Prognosis in WM is highly variable and serum beta 2M was the dominant predictor of a need for therapy and of survival. FAMP has activity against WM. Our staging system may provide guidance for a risk-based approach to the treatment of WM. (C) 2001 by The American Socie ty of Hematology.