Hb. Nader et al., Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells, BRAZ J MED, 34(6), 2001, pp. 699-709
Citations number
30
Categorie Soggetti
Medical Research General Topics
Journal title
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
The anticlotting and antithrombotic activities of heparin, heparan sulfate,
low molecular weight heparins, heparin and heparin-like compounds from var
ious sources used in clinical practice or under development are briefly rev
iewed. Heparin isolated from shrimp mimics the pharmacological activities o
f low molecular weight heparins. A heparan sulfate from Artemia franciscana
and a dermatan sulfate from tuna fish show a potent heparin cofactor II ac
tivity. A heparan sulfate derived from bovine pancreas has a potent antithr
ombotic activity in an arterial and venous thrombosis model with a negligib
le activity upon the serine proteases of the coagulation cascade. It is sug
gested that the antithrombotic activity of heparin and other antithrombotic
agents is due at least in part to their action on endothelial cells stimul
ating the synthesis of an antithrombotic heparan sulfate.