Polymorphisms in inflammatory cytokines and Fc gamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study

Authors
Foster, CB Zhu, SX Erichsen, HC Lehrnbecher, T Hart, ES Choi, E Stein, S Smith, MW Steinberg, SM Imbach, P Kuhne, T Chanock, SJ
Citation
Cb. Foster et al., Polymorphisms in inflammatory cytokines and Fc gamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study, BR J HAEM, 113(3), 2001, pp. 596-599
Citations number
16
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
113
Issue
3
Year of publication
2001
Pages
596 - 599
Database
ISI
SICI code
0007-1048(200106)113:3<596:PIICAF>2.0.ZU;2-4
Abstract
Inflammatory cytokines and low-affinity Fc gamma receptor (Fc gammaR) polym orphisms were investigated in 37 children with chronic immune thrombocytope nic purpura (cITP) and 218 controls. Genotype analysis included common vari ants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, I L4, IL6 and IL10, and structural variants of the low affinity Fc gamma Rs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P = 0.0034). Two combinati ons of genotypes (TNF and FCGR3A; P = 0.0003, and LTA and FCGR3B; P = 0.011 ) were significantly associated with cITP, These results provide preliminar y evidence that variant genotypes of Fc gamma Rs and cytokines contribute t o cITP pathogenesis.