Non-transferrin-bound iron during allogeneic stem cell transplantation

Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) m ight contribute to transplantation-related complications. The occurrence of NTBI in 10 adult allogeneic stem cell transplantation (SCT) patients was f ollowed for 20 d. The transferrin saturation reached 99% on d -4 and remain ed >80% thereafter. NTBI, measured as bleomycin-detectable iron, was detect ed for 6-18 d in all patients with a peak on d -4. High transferrin saturat ion levels were associated with the appearance of NTBI with a threshold at 80% saturation. Prevention of the potential deleterious effects of NTBI mig ht reduce transplantation-related morbidity.