Simian virus 40, asbestos, and the development of malignant mesotheliomas

Authors
Powers, A Rizzo, P Di Resta, I Matker, C Kast, WM Mutti, L Pass, HI Carbone, M
Citation
A. Powers et al., Simian virus 40, asbestos, and the development of malignant mesotheliomas, CAN MINERAL, 2001, pp. 135-140
Citations number
42
Categorie Soggetti
Earth Sciences
Journal title
CANADIAN MINERALOGIST
ISSN journal
00084476 → ACNP
Year of publication
2001
Pages
135 - 140
Database
ISI
SICI code
0008-4476(2001):5<135:SV4AAT>2.0.ZU;2-H
Abstract
Simian virus 40, a DNA tumor virus that causes mesothelioma in hamsters and transforms human cells in tissue culture, has been recently detected in hu man mesotheliomas. In these tumors, the SV40 large-T antigen binds and inac tivates several tumor suppressors, including p53, leaving the cell more vul nerable to other carcinogens, including asbestos.