Correlation between phototoxicity and photoionization efficiency of phenothiazine drugs

Authors
Kojima, M Nebashi, S Nakamura, K Ikeda, T Yatsushiro, A Tajima, S Tobita, S
Citation
M. Kojima et al., Correlation between phototoxicity and photoionization efficiency of phenothiazine drugs, CHEM LETT, (6), 2001, pp. 544-545
Citations number
14
Categorie Soggetti
Chemistry
Journal title
CHEMISTRY LETTERS
ISSN journal
03667022 → ACNP
Issue
6
Year of publication
2001
Pages
544 - 545
Database
ISI
SICI code
0366-7022(20010605):6<544:CBPAPE>2.0.ZU;2-U
Abstract
Irradiation of sodium hyaluronate (NaHA) in the presence of phenothiazine d erivatives (PTZ) caused degradation of the biopolymer. It was found that me asurement of the degradation efficiency was useful for estimation of the ph ototoxicity of the phenothiazine drugs. The results of laser photolysis sug gested that the photoionization of PTZ is a key step in initiating degradat ion of NaHA.