MinK-related peptide 1 - A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation

Authors
Yu, H Wu, J Potapova, I Wymore, RT Holmes, B Zuckerman, J Pan, Z Wang, H Shi, W Robinson, RB El-Maghrabi, MR Benjamin, W Dixon, J McKinnon, D Cohen, IS Wymore, R
Citation
H. Yu et al., MinK-related peptide 1 - A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation, CIRCUL RES, 88(12), 2001, pp. E84-E87
Citations number
11
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
CIRCULATION RESEARCH
ISSN journal
00097330 → ACNP
Volume
88
Issue
12
Year of publication
2001
Pages
E84 - E87
Database
ISI
SICI code
0009-7330(20010622)88:12<E84:MP1-AB>2.0.ZU;2-L
Abstract
The HCN family of ion channel subunits underlies the currents I-f in heart and I-h and I-q in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I-Kr, these results suggest that this pe ptide may have the unique role of regulating both the inward and outward ch annels that underlie cardiac pacemaker activity. The full text of this arti cle is available at http://www.circresaha.org.