Crohn disease and ulcerative colitis are caused by an excessive immune-infl
ammatory reaction in the intestinal wall. Analysis of the types of immune r
esponse ongoing in the inflamed intestine has revealed that in Crohn diseas
e there is predominantly a T helper cell type 1 response, with exaggerated
production of interleukin (IL)-12 and interferon-gamma, whereas in ulcerati
ve colitis the lesion seems to be more of an antibody-mediated hypersensiti
vity reaction. Despite these differences, downstream inflammatory events ar
e probably similar in both conditions. In both Crohn disease and ulcerative
colitis there is an increased synthesis of proinflammatory cytokines, incl
uding IL-1 beta, IL-6, IL-8, IL-16, and tumor necrosis factor-alpha accompa
nying the influx of nonspecific inflammatory cells into the mucosa, These c
ytokines contribute to the tissue damage either directly or indirectly by e
nhancing the production of matrix metalloproteinases and growth factors, wh
ich produce ulceration as well as mucosal repair.