Well-less, gel-permeation formats for ultra-HTS

Authors
Burns, DJ Kofron, JL Warrior, U Beutel, BA
Citation
Dj. Burns et al., Well-less, gel-permeation formats for ultra-HTS, DRUG DISC T, 6(12), 2001, pp. S40-S47
Citations number
21
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUG DISCOVERY TODAY
ISSN journal
13596446 → ACNP
Volume
6
Issue
12
Year of publication
2001
Supplement
S
Pages
S40 - S47
Database
ISI
SICI code
1359-6446(20010615)6:12<S40:WGFFU>2.0.ZU;2-G
Abstract
An alternative approach to miniaturization has been developed that does not rely upon increasing microtiter plate densities. Gel-permeation assays, or iginally developed for screening interactions and anti-microbial screening, are a well-less-technique. Newer approaches extending this technology to e nable the screening of traditional compound-collections show exceptional pr omise and offer the potential to convert most (if not all) 96-well assays i nto this novel high-density format.