Clinical significance of the serum surfactant protein D and KL-6 levels inpatients with measles complicated by interstitial pneumonia

Citation
Y. Arai et al., Clinical significance of the serum surfactant protein D and KL-6 levels inpatients with measles complicated by interstitial pneumonia, EUR J PED, 160(7), 2001, pp. 425-429
Citations number
16
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
EUROPEAN JOURNAL OF PEDIATRICS
ISSN journal
03406199 → ACNP
Volume
160
Issue
7
Year of publication
2001
Pages
425 - 429
Database
ISI
SICI code
0340-6199(200107)160:7<425:CSOTSS>2.0.ZU;2-3
Abstract
To examine the value of surfactant protein D and KL-6 as markers for the di agnosis and the severity of interstitial pneumonia caused by measles infect ion, surfactant protein D, KL-6 and lactic acid dehydrogenase were measured serially in three patients with measles complicated by interstitial pneumo nia as compared to ten measles infected patients without interstitial pneum onia. The serum surfactant protein D and KL-6 levels were higher in patient s with measles and interstitial pneumonia as compared to those with measles without interstitial pneumonia. In patients with measles and interstitial pneumonia, the respiratory distress and the alveolar-arterial oxygen differ ences improved after steroid pulse therapy while the serum surfactant prote in D level decreased dramatically under the cut-off level and earlier than the KL-6 level. On the contrary, the serum KL-6 level increased transiently and it took longer to decrease below the cut-off level as compared to the pattern observed for serum surfactant protein D. The serum lactic acid dehy drogenase level changes were between those of the surfactant protein D and KL-6 levels. Conclusion Surfactant protein D and KL-6 are easily measured and useful mar kers for the diagnosis of interstitial pneumonia caused by measles infectio n. Early decrease of surfactant protein D contrasts with the transient incr ease of KL-6 levels after prednisolone pulse therapy.