Autoradiographic distribution of adrenomedullin receptors in the rat brain

The autoradiographic distribution of putative brain adrenomedullin receptor s was investigated using [(125)]human adrenomedullin(13-52) as a new radiol igand. Specific [I-125]human adrenomedullin(13-52) binding sites were very discretely distributed in the rat brain with enrichment seen in the choroid plexus and linings of the third, fourth and lateral ventricles, basolatera l amygdaloid nuclei, neural lobe of the pituitary gland, the trigeminal ner ves and in the granular cell layer of the cerebellum. To our knowledge, thi s is the first report on the discrete localization of adrenomedullin recept ors in the mammalian brain. (C) 2001 Published by Elsevier Science B.V.