On so-called plasmocytic leukemia with systemic polyorganic specific lesion.

A case of 64-year-old patient is reported in whom multiple myeloma with Ben s-Jones proteinurea stage IIIB ran in the period of making diagnosis by typ e of plasm cell leukemia. In diagnosis, besides common clinical and cytomor phological methods use was made of cytochemical, electron-microscopic and e nzyme immunoassays of plasm blood cells and cells of bone marrow which unde r light microscopy were characterized with some features of atypism peculia r for immature (blast) cells. Immunophenotyping referred them to cells of t he pathological population at the end stage of B-cell differentiation. Resu lts of electron microscopy were also typical for cells well differentiated in the direction of protein synthesis (Ig). Clinically, there were severe d ysfunctions of the kidneys and liver which resulted in a lethal outcome. Th e patient received therapy against chronic renal failure including 41 proce dures of plasmapheresis. Plasm cell leukemia was treated with alkeran, vinc ristine, prednisolone, program M-2 without noticeable effect. The patient d ied in coma and gastrointestinal hemorrhage. The survival from the time of the diagnosis was 4 months. Autopsy confirmed the diagnosis.