K. Iwase et al., Expression of nm23-H1 in hydatidiform mole and its relationship with the development of postmolar disease, GYNECOL OBS, 51(4), 2001, pp. 228-232
The aim of the present study was to investigate the expression of nm23-H1 i
n human placenta, hydatidiform mole and choriocarcinoma cells, Nm23-H1 prot
ein was localized in the cytotrophoblast, but not in the syncytiotrophoblas
t, In the hydatidiform mole cases with subsequent spontaneous remission, nm
23-H1 mRNA levels were significantly lower than those in first-trimester pl
acentas, However, its levels were elevated in the hydatidiform mole cases t
hat progressed to persistent gestational trophoblastic disease and were com
parable to those of first-trimester placentas, and they were further elevat
ed in choriocarcinoma cells, The present data suggest an association of nm2
3-H1 for the proliferation activity of trophoblast, and its increased expre
ssion may influence the development of persistent trophoblastic disease, Co
pyright (C) 2001 S. Karger AG. Basel.