No substantial difference in genotype frequencies of interleukin and myeloperoxidase polymorphisms between malignant lymphoma patients and non-cancercontrols

Background and Objectives. The functional polymorphisms regulating immunolo gic responses may influence the proliferation or suppression of malignant l ymphoma. We examined the association between malignant lymphoma risk and th e polymorphisms of the IL-1 gene family [IL-1B -31 C/T, IL-1A -889 C/T, and IL-1RN 86-bp variable number of terminal repeat (VNTR)] and myeloperoxidas e (MPO -463 G/A). Design and Methods. The hospital-based case-control study was conducted in Japan. Genotypes were examined in a total of 372 lymphoma cases and 241 non -cancer control subjects. The relative risks were estimated by unconditiona l logistic regression analysis. Results. The overall allele distribution of these polymorphisms did not dif fer substantially between patients and controls; the odds ratios were 0.73 (95% confidence interval, 0.48-1.11) for the T allele carders of IL-1B rela tive to the non-carriers, 1.01 (0.56-1.82) for the repeat allele (allele 2) carders of IL-1RN, 0.96 (0.62-1.48) for the T allele carriers of IL-1A, an d 1.04 (0.70-1.57) for the A allele carriers of MPO. Subgroup analyses acco rding to histology [diffuse large B-cell lymphoma (DLBL), follicular lympho ma, low-grade lymphoma of mucosa associated lymphoid tissue, and others] fa iled to illustrate differences except for DLBL which showed a possible asso ciation with IL-1A and IL-1B polymorphisms. Interpretation and Conclusions. Our data show a limited association between these polymorphisms and malignant lymphoma risk in total. The possible ass ociation of the IL-1A and IL-1B polymorphisms with DLB-needs further clarif ication. (C) 2001, Ferrata Stolti Foundation.