An improved hydrolysis of 7 alpha-chloro-7 beta-cyano-6,14-endo-ethenotetrahydrothebaine to its 7-oxo derivative

Authors
Maeda, DY Coop, A
Citation
Dy. Maeda et A. Coop, An improved hydrolysis of 7 alpha-chloro-7 beta-cyano-6,14-endo-ethenotetrahydrothebaine to its 7-oxo derivative, HETEROCYCLE, 55(6), 2001, pp. 1147-1149
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
55
Issue
6
Year of publication
2001
Pages
1147 - 1149
Database
ISI
SICI code
0385-5414(20010601)55:6<1147:AIHO7A>2.0.ZU;2-W
Abstract
An efficient method for the conversion of 7 alpha -chloro-7 beta -cyano-6,1 4-endo-ethenotetrahydrothebaine (4) to 6,14-endo-etheno-7-oxotetrahydrotheb aine (3) using Na2S . 9H(2)O is described. This method requires no chromato graphy for purification, and is therefore amenable to large scale preparati on of the potentially important opioid intermediate.