Natural camptothecins

Authors
Das, B Madhusudhan, P Reddy, PV Anitha, Y
Citation
B. Das et al., Natural camptothecins, I J CHEM B, 40(6), 2001, pp. 453-464
Citations number
66
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
40
Issue
6
Year of publication
2001
Pages
453 - 464
Database
ISI
SICI code
0376-4699(200106)40:6<453:NC>2.0.ZU;2-3
Abstract
Camptothecin, a novel pyrrolo[3,4-b]-quinoline alkaloid, is a lead anticanc er agent of the recent years. The compound and its several analogues (colle ctively known as camptothecins) have been reported from different botanical species. The former is also a promising drug in the AIDS chemotherapy. Sev eral other camptothecins also exhibit significant antitumour and anti-HIV p roperties. The literature concerning the chemistry and bioactivity of these natural camptothecins has been briefly reviewed.