Microscopic polyangiitis associated with sinobronchial syndrome

A woman with a long history of chronic bronchitis and chronic sinusitis, i. e., sinobronchial syndrome, was admitted with a fever. Radiologically, ther e were areas of longstanding consolidation in both lungs, with areas of act ive inflammation demonstrated by gallium-67 scintigraphy, Antineutrophil cy toplasmic antibody specific for myeloperoxidase was highly positive, Pulmon ary hemorrhage and hematuria occurred 2 weeks after admission and responded to steroid therapy. However the patient died of pneumonia, An autopsy reve aled systemic necrotizing vasculitis affecting multiple organs, consistent with microscopic polyangiitis, The vasculitis might have been caused by the chronic inflammation in the lungs associated with sinobronchial syndrome.