Evaluation of chemotherapy response using technetium-99m-sestamibi scintigraphy in untreated adult malignant lymphomas and comparison with other prognosis factors: A preliminary report
Ch. Kao et al., Evaluation of chemotherapy response using technetium-99m-sestamibi scintigraphy in untreated adult malignant lymphomas and comparison with other prognosis factors: A preliminary report, INT J CANC, 95(4), 2001, pp. 228-231
The purpose of this study was to predict chemotherapy response using techne
tium-99m methoxyisobutylisonitrile (Tc-MIBI) scintigraphy in untreated adul
t malignant lymphomas (ML) and compare the response with of her prognosis f
actors. Before chemotherapy, 25 adult patients with ML were enrolled in thi
s study. Tc-MIBI scintigraphy was performed 10 min after intravenous inject
ion of Tc-MIBI to calculate tumor-to-background (T/B) uptake ratio and inte
rpret the results visually. Chemotherapy response was evaluated in the firs
t 1 to 2 years after completion of treatment by clinical and radiological m
ethods. The mean TIE uptake ratio of the 15 patients with good response (3.
3 +/- 0.6) was significantly higher than that of the 10 patients with poor
response (1.2 +/- 0.1), All of the 15 patients with good response had posit
ive Tc-MIBI scintigraphic results. All of the 10 patients with poor respons
e had negative Tc-MIBI scintigraphic results, However, there were no signif
icant differences in the incidences of good and poor responses For other pr
ognosis factors. In our preliminary study, when compared with other prognos
is factors, Tc-MIBI scintigraphy was the best tool to predict chemotherapy
response in adult patients with ML. (C) 2001 Wiley-Liss, Inc.