Ovarian endometriosis and clear cell carcinoma, leiomyomatosis peritonealis dissesminata, and endometrial adenocarcinoma: An unusual, pathogenetically related association

Citation
R. Guarch et al., Ovarian endometriosis and clear cell carcinoma, leiomyomatosis peritonealis dissesminata, and endometrial adenocarcinoma: An unusual, pathogenetically related association, INT J GYN P, 20(3), 2001, pp. 267-270
Citations number
18
Categorie Soggetti
Reproductive Medicine
Journal title
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
ISSN journal
02771691 → ACNP
Volume
20
Issue
3
Year of publication
2001
Pages
267 - 270
Database
ISI
SICI code
0277-1691(200107)20:3<267:OEACCC>2.0.ZU;2-V
Abstract
A 42 year-old female with a preoperative clinical diagnosis of ovarian canc er underwent laparotomy which revealed leiomyomatosis peritonealis dissemin ata (LPD) in the peritoneum and omentum and a left ovarian endometriotic cy st associated with a clear cell carcinoma. A grade I, superficially invasiv e villoglandular endometrial endometrioid adenocarcinoma was also found. Mi croscopically, the endometriotic cyst wall contained an extensive periphera l band-like condensation of stromal cells. These cells were strongly positi ve for alpha inhibin and may have been the hormonal source responsible for the induction of the simultaneous LPD and endometrial adenocarcinoma. It is proposed that endometriosis is not only a precursor of clear cell carcinom a but, through secondary hormonal induction of the surrounding ovarian stro ma, may also provide a hormonal stimulus for diverse proliferative processe s.