Pulmonary T cells and eosinophils: Coconspirators or independent triggers of allergic respiratory pathology?

Etiologic discussions of allergic respiratory pathology frequently engender rabid constituencies of pro-T cell or proeosinophil disciples, each claimi ng, often with religious fervor, the importance of their leukocyte, However increasing evidence suggests that the exclusionary rhetoric from either ca mp is inadequate to explain many of the pathologic changes occurring in the lung, Data from both asthmatic patient and mouse models of allergic respir atory inflammation suggest that, in addition to cell-autonomous activities, T-cell and eosinophil interactions may be critical to the onset and progre ssion of pulmonary pathology. These studies also suggest that T-lymphocyte subpopulations and eosinophils communicate by means of both direct cell-cel l interactions and through the secretion of inflammatory signals. Collectiv ely, the data support an expanded view of T-cell and eosinophil activities in the lung, including both immunoregulative activities and downstream effe ctor functions impinging directly on lung function.