Spontaneous erythromycin resistance mutation in a 23S rRNA gene, rrlA, of the extreme thermophile Thermus thermophilus IB-21

Authors
Gregory, ST Cate, JHD Dahlberg, AE
Citation
St. Gregory et al., Spontaneous erythromycin resistance mutation in a 23S rRNA gene, rrlA, of the extreme thermophile Thermus thermophilus IB-21, J BACT, 183(14), 2001, pp. 4382-4385
Citations number
33
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
183
Issue
14
Year of publication
2001
Pages
4382 - 4385
Database
ISI
SICI code
0021-9193(200107)183:14<4382:SERMIA>2.0.ZU;2-H
Abstract
Spontaneous, erythromycin-resistant mutants of Thermus thermophilus IB-21 w ere isolated and found to carry the mutation A2058G in one of two 23S rRNA operons. The heterozygosity of these mutants indicates that A2058G confers a dominant or codominant phenotype in this organism. This mutation provides a valuable tool for the genetic manipulation of the 23S rRNA genes of Ther mus.