Multiple genes for the last step of proline biosynthesis in Bacillus subtilis

Authors
Belitsky, BR Brill, J Bremer, E Sonenshein, AL
Citation
Br. Belitsky et al., Multiple genes for the last step of proline biosynthesis in Bacillus subtilis, J BACT, 183(14), 2001, pp. 4389-4392
Citations number
33
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
183
Issue
14
Year of publication
2001
Pages
4389 - 4392
Database
ISI
SICI code
0021-9193(200107)183:14<4389:MGFTLS>2.0.ZU;2-I
Abstract
The complete Bacillus subtilis genome contains four genes (proG, proH, proI , and comER) with the potential to encode Delta (1)-pyrroline-5-carboxylate reductase, a proline biosynthetic enzyme. Simultaneous defects in three of these genes (proG, proH, and proI) were required to confer proline auxotro phy, indicating that the products of these genes are mostly interchangeable with respect to the last step in proline biosynthesis.