The purpose of the present study was to systematically compare the psycholo
gical and screening profiles of first-degree relatives (FDRs) of prostate c
ancer patients versus non-FDRs. FDRs (n = 56) and non-FDRs (n = 100), recru
ited through prostate cancer index cases and newspaper advertisements, comp
leted questionnaires via mail. FDRs reported feeling at greater risk for pr
ostate cancer, estimated that they were at higher average lifetime risk for
the disease, agreed more strongly that prostate cancer is inherited, and t
hat less can be done to prevent the development of the disease, lncreased a
ge, but not FDR status, was associated with more frequent screening behavio
r Taken together, the results indicate that FDRs; are characterized by grea
ter perceived vulnerability to prostate cancer and lower expectations about
disease prevention. Yet, they are no more likely to be screened than non-F
DRs. These findings underscore the importance of developing, and evaluating
, evidence-based health communication protocols to promote screening adhere
nce among at-risk patients.