An open-label trial of tomoxetine in pediatric attention deficit hyperactivity disorder

Objective: To collect pilot data assessing the safety, tolerability, and ef ficacy of tomoxetine, a nonstimulant norepinephrine enhancer, in pediatric attention deficit hyperactivity disorder (ADHD). Methods: An open-label trial of tomoxetine in pediatric ADHD was conducted as part of a multisite clinical trial. Following a baseline assessment, an ascending dose titration was completed during 10 weekly visits. Results: Ten subjects were enrolled at baseline, with eight completing the study. Seven of the eight remaining subjects met efficacy criteria. Signifi cant decreases in symptom severity ratings by parents and study investigato rs were found. The medication was well tolerated, with transient appetite s uppression the most frequently reported side effect. However, subjects' wei ghts remained stable across study visits. Discussion: These preliminary findings suggest that tomoxetine may hold pro mise as a treatment for pediatric ADHD.