Variation in the timing of puberty: Clinical spectrum and genetic investigation

Human puberty begins with the reemergence of GnRH secretion from its relati ve quiescence during childhood, activating a cascade of pituitary-gonadal m aturation. This transition begins across a wide range of ages, and the rate of subsequent sexual maturation can be quite varied. The factors that regu late the hypothalamic-pituitary-gonadaI axis and modulate the timing of pub erty remain elusive, but it is clear that some regulation is under genetic control. Here, we discuss how new advances in genetic research may provide the tools to help unravel this long-standing mystery.