Severe toxic hepatitis associated with amoxycillin and clavulanic acid

Toxic hepatitis secondary to amoxycillin-clavulanic acid is an infrequent c linical picture. Most of the cases are reported to have a benign course. We report two cases of severe hepatic failure following amoxycillin-clavulani c acid use. One of the cases had cholestatic features primarily, and the ot her had hepatocellular injury prominently. The first case had also findings of trombotic trombositic purpura and had a fatal course.